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How NovoLog® is Different

What are the benefits of NovoLog®?

NovoLog® (insulin aspart [rDNA origin] injection) is a fast-acting (also called rapid-acting) insulin designed to work like the insulin that the body makes after meals. It is called an insulin analog, which is a slightly altered form of the insulin made by the body. This allows NovoLog® to be absorbed more quickly by the body. Since it is absorbed quickly, NovoLog® acts fast to provide the insulin response needed by the body at mealtime.

NovoLog® and nighttime blood sugar

NovoLog® has a low rate of nighttime low blood sugar, or nocturnal hypoglycemia. In a study of people with type 1 diabetes, people taking NovoLog® had fewer nighttime low blood sugar episodes than those taking regular human insulin. Learn more about the signs and symptoms of low blood sugar on Cornerstones4Care.com.

NovoLog® can keep up with
your routine

NovoLog® works differently than regular human insulin. NovoLog® is fast-acting, so it can be taken just before your meal, whenever you prefer to eat. This may help you live your life on your schedule when it comes to exercising, activities with friends, and times when you are on the go. Be sure to consult with your doctor to adjust your insulin level for these types of changes in your daily schedule.

NovoLog® is stable in storage

NovoLog® FlexPen®, 3-mL PenFill® cartridge, and 10-mL vial do not need to be refrigerated once they've been opened, so they can be stored on a nightstand, in a purse, and many other places.

NovoLog® FlexPen®, 3-mL PenFill® cartridge, and 10-mL vial: stable in storage

Temperature Storage
In use‡§
(opened)
Room temperature
(up to 86°F)
28 days
Not in use
(unopened)
Room temperature
(up to 86°F)
28 days
Not in use
(unopened)
Refrigerated Until expiration date

NovoLog®: designed to take the heat

  • NovoLog® in the 3-mL PenFill® cartridge and vial is stable at temperatures up to 86°F once in use (opened) and does not require refrigeration
  • NovoLog® remains heat stable in pumps at normal body temperature (up to 98.6°F)

NovoLog®: designed to take the heat

  • NovoLog® in the 3-mL PenFill® cartridge and vial is stable at temperatures up to 86°F once in use (opened) and does not require refrigeration
  • NovoLog® remains heat stable in pumps at normal body temperature (up to 98.6°F)

NovoLog®: more time between insulin changes in pumps

  • NovoLog® is the first and only rapid-acting insulin with an extended in-use time of up to 6 days in external insulin pump reservoirs

NovoLog® is safe and effective for use in a pump

NovoLog® has been approved for use in pumps since 2001. NovoLog® has been proven safe and effective for use in insulin pumps in children age 2 and older with type 1 diabetes and adults with diabetes.

NovoLog® is the first fast-acting insulin that can be used for up to 6 days in a pump reservoir before it needs to be changed. When used in a pump, NovoLog® had a lower rate of clogs compared with other insulin analogs. Learn more about using NovoLog® in a pump.

When considering NovoLog® or NovoLog® in a pump, it is important to have a good understanding of how NovoLog® works.

Indications and Usage

What is NovoLog® (insulin aspart [rDNA origin] injection)?

  • NovoLog® is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

Important Safety Information

Who should not take NovoLog®?

Do not take NovoLog® if:

  • your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients.

Before taking NovoLog®, tell your health care provider about all your medical conditions including, if you are:

  • pregnant, plan to become pregnant, or are breastfeeding.
  • taking new prescription or over-the-counter medicines, including supplements.

Talk to your health care provider about how to manage low blood sugar.

How should I take NovoLog®?

  • Read the Instructions for Use and take exactly as directed.
  • NovoLog® is fast-acting. Eat a meal within 5 to 10 minutes after taking it.
  • Know the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to.
  • Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them.
  • Do not share needles, insulin pens, or syringes. You may give or get an infection from another person.

What should I avoid while taking NovoLog®?

  • Do not drive or operate heavy machinery, until you know how NovoLog® affects you.
  • Do not drink alcohol or use medicines that contain alcohol.

What are the possible side effects of NovoLog®?

Serious side effects can lead to death, including:

Low blood sugar. Some signs and symptoms include:

  • anxiety, irritability, mood changes, dizziness, sweating, confusion, and headache.

Your insulin dose may need to change because of:

  • weight gain or loss, increased stress, illness, or change in diet or level of physical activity.

Other common side effects may include:

  • low potassium in your blood, injection site reactions, itching, rash, serious whole body allergic reactions, skin thickening or pits at the injection site, weight gain, and swelling of your hands and feet.

Get emergency medical help if you have:

  • trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, or confusion.

For more information, please click here for complete NovoLog® Prescribing Information.

NovoLog® is a prescription medicine.

Talk to your doctor about the importance of diet and exercise in your treatment plan.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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If you need assistance with prescription drug costs, help may be available. Visit pparx.org or call 1-888-4PPA-NOW.

Selected Important Safety Information

Who should not take NovoLog®?

Do not take NovoLog® if:

  • your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients.

How should I take NovoLog®?

  • Read the Instructions for Use and take exactly as directed.
  • NovoLog® is fast-acting. Eat a meal within 5 to 10 minutes after taking it.
  • Know the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to.
  • Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them.
  • Do not share needles, insulin pens, or syringes. You may give or get an infection from another person.

Please click here for additional Important Safety Information

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