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How NovoLog® is Different

What are the benefits of NovoLog®?

NovoLog® (insulin aspart [rDNA origin] injection) is a fast-acting (also called rapid-acting) insulin designed to work like the insulin that the body makes after meals. It is called an insulin analog, which is a slightly altered form of the insulin made by the body. This allows NovoLog® to be absorbed more quickly by the body. Since it is absorbed quickly, NovoLog® acts fast to provide the insulin response needed by the body at mealtime.

NovoLog® and nighttime blood sugar

NovoLog® has a low rate of nighttime low blood sugar, or nocturnal hypoglycemia. In a study of people with type 1 diabetes, people taking NovoLog® had fewer nighttime low blood sugar episodes than those taking regular human insulin. Learn more about the signs and symptoms of low blood sugar on Cornerstones4Care.com.

NovoLog® can keep up with
your routine

NovoLog® works differently than regular human insulin. NovoLog® is fast-acting, so it can be taken just before your meal, whenever you prefer to eat. This may help you live your life on your schedule when it comes to exercising, activities with friends, and times when you are on the go. Be sure to consult with your doctor to adjust your insulin level for these types of changes in your daily schedule.

NovoLog® is stable in storage

NovoLog® FlexPen®, 3-mL PenFill® cartridge, and 10-mL vial do not need to be refrigerated once they've been opened, so they can be stored on a nightstand, in a purse, and many other places.

NovoLog® FlexPen®, 3-mL PenFill® cartridge, and 10-mL vial: stable in storage

Temperature Storage
In use‡§
(opened)
Room temperature
(up to 86°F)
28 days
Not in use
(unopened)
Room temperature
(up to 86°F)
28 days
Not in use
(unopened)
Refrigerated Until expiration date

NovoLog®: designed to take the heat

  • NovoLog® in the 3-mL PenFill® cartridge and vial is stable at temperatures up to 86°F once in use (opened) and does not require refrigeration
  • NovoLog® remains heat stable in pumps at normal body temperature (up to 98.6°F)

NovoLog®: designed to take the heat

  • NovoLog® in the 3-mL PenFill® cartridge and vial is stable at temperatures up to 86°F once in use (opened) and does not require refrigeration
  • NovoLog® remains heat stable in pumps at normal body temperature (up to 98.6°F)

NovoLog®: more time between insulin changes in pumps

  • NovoLog® is the first and only rapid-acting insulin with an extended in-use time of up to 6 days in external insulin pump reservoirs

NovoLog® is safe and effective for use in a pump

NovoLog® has been approved for use in pumps since 2001. NovoLog® has been proven safe and effective for use in insulin pumps in children age 2 and older with type 1 diabetes and adults with diabetes.

NovoLog® is the first fast-acting insulin that can be used for up to 6 days in a pump reservoir before it needs to be changed. When used in a pump, NovoLog® had a lower rate of clogs compared with other insulin analogs. Learn more about using NovoLog® in a pump.

When considering NovoLog® or NovoLog® in a pump, it is important to have a good understanding of how NovoLog® works.

Indications and Usage

What is NovoLog® (insulin aspart [rDNA origin] injection)?

NovoLog® is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

Important Safety Information

Who should not use NovoLog®?

Do not use NovoLog® if your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients.

What should I tell my health care provider before taking NovoLog®?

About all of your medical conditions, including liver, kidney, or heart problems.
If you are pregnant, breastfeeding, or plan to do either.
About all prescription and nonprescription medicines you take, including supplements, as your dose may need to change.

How should I take NovoLog®?

Eat a meal within 5 to 10 minutes after using NovoLog®, a fast-acting insulin, to avoid low blood sugar. Do not inject NovoLog® if you do not plan to eat right after your injection or bolus pump infusion.
Do not mix NovoLog® with any other insulin when used in a pump or with any insulin other than NPH when used with injections by syringe.
Do not change your dose or type of insulin unless you are told to by your health care provider.
Do not share needles, insulin pens, or syringes.
Check your blood sugar levels as directed by your health care provider.

What should I consider while using NovoLog®?

Alcohol, including beer and wine, may affect your blood sugar.
Be careful when driving a car or operating machinery. You may have difficulty concentrating or reacting if you have low blood sugar. Talk to your health care provider if you often have low blood sugar or no warning signs of low blood sugar.

What are the possible side effects of NovoLog®?

Low blood sugar, including when too much is taken. Some symptoms include sweating, shakiness, confusion, and headache. Severe low blood sugar can cause unconsciousness, seizures, and death.
Serious allergic reactions may occur. Get medical help right away, if you develop a rash over your whole body, have trouble breathing, a fast heartbeat, or sweating.
Other side effects include injection site reactions (like redness, swelling, and itching), skin thickening or pits at the injection site, swelling of your hands and feet, if taken with thiazolidinediones (TZDs) possible heart failure, vision changes, low potassium in your blood, and weight gain.

For more information, please click here for complete NovoLog® Prescribing Information.

NovoLog® is a prescription medicine.

Talk to your doctor about the importance of diet and exercise in your treatment plan.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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If you need assistance with prescription drug costs, help may be available. Visit pparx.org or call 1-888-4PPA-NOW.

Selected Important Safety Information

What are the possible side effects of NovoLog®?

• Low blood sugar, including when too much is taken. Some symptoms include sweating, shakiness, confusion, and headache. Severe low blood sugar can cause unconsciousness, seizures, and death.

• Other side effects include injection site reactions (like redness, swelling, and itching), skin thickening or pits at the injection site, swelling of your hands and feet, if taken with thiazolidinediones (TZDs) possible heart failure, vision changes, low potassium in your blood, and weight gain.

Please click here for additional Important Safety Information

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